One Two
We gratefully acknowledge funding from the DFG via the Emmy Noether Programme and the FCI.


  • Larissa receives the Thieme Chemistry Journals Award 2023
  • Larissa joins the Editorial Advisory Board of ChemSystemsChem (Chemistry Europe)
  • New publication in Angew. Chem. Int. Ed.
    Great Collaboration with Jieyu Zheng and Jonathan Nitschke
  • Congratulations to Fabian, Justin, and Jonathan for successfully finishing their Bachelor theses! We wish you all the best for your future endeavours!
  • A warm welcome to our Master's students Anne and Vigan!
  • Larissa receives the 2021 Teaching Award of the faculty.
  • The Krbek Group attends SupraChem 2022 in Mainz.
  • A warm welcome to our Bachelor students Fabian, Jonathan, & Justin!
  • Larissa gets highlighted in the Chemical Science Reviewer Spotlight
  • Larissa is guest editor
    for a Supramolecular Chemistry special issue on first generation supramolecular chemists. Click here for the call for papers.
  • Congratulations to Damiano Tolazzi for successfully finishing his Master's thesis! We wish you all the best for your future endeavours!
  • Congratulations to Ruben Falkenburg for successfully finishing his Master's thesis! We're looking forward to keeping you on as a PhD student!
  • Lidón Pruñonosa Lara joins the group as PhD student!
  • Larissa presents at the 3rd NOAH ITN Summer School:
    Kinetic and Thermodynamic characterisation tools for supramolecular complexes.
  • Larissa talks at the 2021 Systems Chemistry Virtual Symposium.
  • Larissa gets named reviewer of the month for Commun. Chem.
  • Emmy Noether funding officially starts!
    We're exited about all the research, that will be facilitated by this funding and are celebrating over some Italian lunch. 
  • Larissa gets named reviewer of the month by Commun. Chem.
  • Damiano Tolazzi joins the group as Master's student!
  • ChemSystemsMeet was a success!
    A big thanks to everyone involved!
  • Ruben Falkenburg joins the group as Master's student!
  • Max Notheis joins the group as PhD student!
  • Wiebke Rautenberg joins the group as PhD student!
  • New publication in Angew. Chem. Int. Ed.
    Another great work with Dong Yang and collaborators from all over the world incl. Biao Wu and John Thoburn
  • New publication in JACS
    Great collaboration with my dear colleagues Dong Yang, Jake Greenfield, and Tanya Ronson.
  • Emmy Noether project gets funded
    The Krbek Group's research will be funded by the Emmy Noether Programme (DFG) from 01/07/2021.
  • New publication in Chem. Sci.
  • The adventure begins... 
    Dr. von Krbek is kicking off her independent career as a junior research group leader (Habilitandin) at Kekulé-Institute for Organic Chemistry and Biochemistry funded by a Liebig Fellowship (FCI).
You are here: Home Research

Research interests

Most supramolecular self-assembly processes are thermodynamically driven, i.e. energetically high components assemble into a thermodynamically more favourable structure. In contrast, natural systems predominantly operate far from equilibrium through the dissipation of energy — i.e. their assembly is driven by the consumption of a fuel, allowing for greater structural complexity, spatiotemporal control over function, self-healing, adaptivity, emergent behaviour, and the ability to perform work. Implementing such out-of-equilibrium (OOE) processes into synthetic systems will lead to greater complexity and function in man-made materials. Furthermore, investigation of these man-made out-of-equilibrium systems might provide a better understanding of the kinetic and thermodynamic constraints in living systems.

Our aim is to design and investigate new metallo-supramolecular systems that assemble through the dissipation of energy using chemical, electrochemical, and photochemical “fuels”, with the final goal of furthering our understanding of out-of-equilibrium systems and emergent behaviour.


Figure. (a) Free energy landscape of a classic self-assembly. (b) Free energy landscape of a dissipative self-assembly. Only the activated building blocks (green) can assemble. Activation of building blocks occurs via energy uptake (chemical fuel or light). Deactivation occurs via dissipation of energy (consumption of fuel). Once the fuel is consumed, the deactivated precursors (blue) cannot stay in the assembled state, the assembly is destroyed, and the system reverts to the thermodynamic equilibrium: the blue non-assembling precursors. (c) A dissipative self-assembly is coupled to an energy-driven chemical reaction network of at least two irreversible reactions: the activation and the deactivation reaction.




Die meisten supramolekularen Selbstorganisationsprozesse sind thermodynamisch getrieben, d.h., dass sich die einzelnen Komponenten unter Freisetzung von Energie zu einem energetisch günstigeren Aggregat anordnen. In der Natur laufen solche Prozesse hingegen meist abseits des thermodynamischen Gleichgewichtes durch die Dissipation von Energie ab, d.h., ihre Selbstorganisation wird durch den Verbrauch eines „Brennstoffes“ angetrieben. Dies ist ein Grund, warum sich biologische Systeme durch eine große strukturelle Komplexität, die Möglichkeit zur räumlichen und zeitlichen Kontrolle ihrer Funktionen, die Fähigkeiten zur Anpassung an neue Umgebungsbedingungen, zur Selbstheilung und zur Verrichtung von Arbeit sowie durch emergentes Verhalten auszeichnen.

Unser Ziel ist es, neue metallo-supramolekularer Systeme zu entwickeln, welche sich durch die Dissipation von Energie anordnen mithilfe chemischer, eletro- und photochemischer Brennstoffe, um dadurch auf lange Sicht ein größeres Verständnis von Systemen außerhalb des thermodynamischen Gleichgewichts und emergenten Verhaltens zu erlangen.

Document Actions